Image of The Antimalarial Activity of the Water Extract of Simpur (Dillenia Indica L) Leaves against Plasmodium Berghei in Mice

Text

The Antimalarial Activity of the Water Extract of Simpur (Dillenia Indica L) Leaves against Plasmodium Berghei in Mice



ABSTRACT
Submitted : 07-09-2018
Revised : 27-03-2019
Accepted : 10-04-2019

Malaria, caused by the climate of the subtropical area and the forest with many rivers and immovable water,
is a contagious disease that still becomes a health problem in West Kalimantan. Simpur is a plant that is
used by the locals to cure malaria. Therefore, this research aims to study the antimalarial activity in vivo and
the 50% inhibitory concentration (IC
50
) of the water extract of Simpur leaves (Dillenia indica L) against
Plasmodium berghei. This research used Peter Test method that used 7 test groups based on the test solution
namely positive control group that was given dihydroartemisinin+piperaquine (DHP), negative control that
was given aquabidestilata and the test group that was given the water extract of Simpur leaves with various
doses of 20, 40, 60, 80 and 100 mg/Kg BB of mice, which each group was given the test solution for 3 days.
The result shows that the water extract of Simpur leaves could lower the parasitemia count with IC
50
19,22
mg/kg BB.
Keywords: Dillenia indica L., antimalarial, in vivo, Plasmodium berghei


Availability

No copy data


Detail Information

Series Title
Vol. 24(1)
Call Number
-
Publisher Traditional Medicine Journal : Yogyakarta.,
Collation
p 28-32
Language
English
ISBN/ISSN
ISSN-p : 1410-5918 I
Classification
NONE
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Specific Detail Info
-
Statement of Responsibility

Other version/related

No other version available


File Attachment



Information


RECORD DETAIL


Back To PreviousXML DetailCite this